Effect of Parathyroids on Radio-Calcium Uptake and Exchange in Rat Tissues. ∗

Abstract

Summary

This study has presented two factors which can markedly affect the uptake and distribution of Ca⁴⁵ in tissues of the rat. The first of these was concerned with the influence of the carrier calcium accompanying the radio element and emphasizes the need for carefully controlled experiments if even small amounts of carrier are administered with the Ca⁴⁵. The second factor was concerned with the influence of parathyroidectomy on the uptake of Ca⁴⁵. The uptake by bone was divided into two time periods, the “exchange period” and the “turnover rate” portion. The exchange period was not markedly affected by the absence of the parathyroids while the turnover of calcium in the bone was at a significantly lower rate.