Abstract
Summary
1. The treatment of Sprague-Dawley rats bearing Flexner-Jobling carcinoma with 2,4,6-triethylenimino-s-triazine resulted in complete regression and cures of the tumor in about 70% of the animals treated. There were no spontaneous regressions among the controls. 2. This carcinoma responded to treatment with doses ranging from 0.016 to 0.046 mg/kg, injected twice daily for the entire course of treatment and the rats showed no marked symptoms of toxicity. 3. A short course of treatment with 0.230 mg/kg/D divided in 4 equal doses and given but 4 days, resulted in complete regressions of the tumors in all of the animals treated when the therapy was begun 8 days after the implantation but this method did not give equally good results in another group treated 11 days after implantation. In this case it was necessary to institute a second course of treatment with 0.052 mg/kg, twice daily for 34 days to obtain complete regression of the tumors in 50% of the animals. 4. All of the rats in which the tumor regressed completely were then resistant to further implants of the tumor. 5. Rats that were cured lived for more than a year without the tumor reappearing. In comparison with the controls they were normal. 6. No gross manifestations of toxicity were seen with the therapeutic doses of TEM used. 7. There was no evidence of carcinogenicity of TEM in the therapeutic doses used in the Sprague-Dawley rats up to one year after the end of the period of therapy.
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