Abstract
Summary
1. It appears as though the riboflavin requirement for antibody production is not as critical as the folic acid requirement. 2. This study indicates that both riboflavin and folic acid deficiencies impaired the production of circulating complement-fixing antibodies when relatively small amounts of antigen were injected. However, after more antigen was introduced, significant titers were obtained from the sera of riboflavin deficient rats but the folic acid deficient animals produced significantly less antibody. The inanition control (paired-weighed) and the normal control animals (fed ad libitum) demonstrated antibody production of approximately the same titers when injected with either 0.0073 mg N or 0.0365 mg N. Therefore, it appears as though the specific vitamin deficiency and not the inanition is the significant factor in the production of circulating complement-fixing antibody.
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