Abstract
Summary
The activities of the triazine metabolites of chlorguanide and dichlorguanide have been studied in P. cynomolgi infections in the rhesus monkey. The results show that the chlorguanide metabolite, CPT, has only one-half to one-fourth the activity of the parent drug, whereas the dichlorguanide metabolite, DCPT, has activity equal to that of chlorguanide. These findings are in marked contrast to reported results on P. gallinaceum infections in the chick, against which CPT and DCPT are respectively 10 and 100 times as effective as chlorguanide.
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