Effects of Prolonged High Dosage with Ascorbic Acid. ∗

Abstract

Results and Conclusion

The data for the 4 subjects were so concordant, they have been averaged together and treated as replicates. There is clearly no progressive change in either the serum or white cell level, tolerance curve, or urinary excretion (Table I). The averages obscure the fact that the individual tolerance curves differed a little in shape. However, the individual character of the curves remained essentially unchanged throughout. There seems, therefore, to be no reason to believe that the prolonged high dosage of ascorbic acid had any qualitative or quantitative effect on the manner of disposal of excess acid by the body. Furthermore, in these fourpersons, at least, no harmful effects whatever were observed during the 3 months with 1000 mg daily intake.