Comparison of Insulin Hypersensitivity of Adrenalectomized and of Hypophysectomized Dogs. ∗ †

Abstract

Summary and Conclusions

The adrenaleo-tomized dog is more sensitive to insulin than the normal dog but less sensitive than the hypophysectomized dog. This is true so long as the adrenalectomized dog, whether with or without DCA maintenance, is still well-nourished and tested only in the post-absorptive state. It is concluded that the adrenal cortical atrophy is an important factor in the production of the insulin hypersensitivity of the hypophysectomized dog. However, absence of an anterior pituitary factor (other than ACTH) is also of great importance in the production of this metabolic abnormality.