Pulmonary Edema in Oxygen Poisoning. ∗

Abstract

Conclusion

When guinea pigs are placed in an environment of 95 to 99% oxygen at ground level barometric pressure 73 to 75 cm Hg, the animals will develop pulmonary edema as a symptom of oxygen poisoning after 48 hours. The condition becomes progressively worse, and the animals die after 4 to 6 days in the oxygen atmosphere. Lung analyses during severe oxygen poisoning indicate an approximate doubling in lung weight and soluble protein nitrogen. Pulmonary hemoglobin, while quite variable in amount in different lungs, does not increase significantly in the entire lung during oxygen poisoning, but local regions, as shown by histological examination, may be intensely congested.