Abstract
Summary
It was observed that only at the 19/20 probability limits did hyaluronidase increase the toxicity of procaine injected subcutaneously into mice. Hyaluronidase did not increase the toxicity of tetracaine within these same limits. From determinations of the procaine in blood of mice at various time intervals after its subcutaneous injection, it was observed that the procaine blood level increased rapidly beginning with the second minute and reached its peak at the eighth minute. The procaine blood level remained unifiorm between the eighth and twentieth minutes after injection. When hyaluronidase was mixed with the procaine injected subcutaneously there was a more rapid rate of increase of the procaine blood level than that of the control but the maximal procaine #blood levels in the 2 groups were the same.
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