Abstract
Summary
Out of a group of compounds, including bishydroxycoumarin, ethyl biscoumacetate, and 17 analogues of indandione, tested in rabbits, 2-diphenylacetyl 1,3-indandione (U-1363) demonstrated the greatest hypoprothrombinemic potency. The prothrombinopenic response of rabbits to acute and chronic doses of U-1363 are reported. Histopathologic observations are reported for rabbits that were given U-1363 daily for several weeks. Acute and chronic toxicity data are reported for U.1363. Vit. K1, but not a water-soluble vit. K analogue. Is an antidote to the hypoprothrombinemia produced by U-1363.
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