Abstract
Summary and conclusions
1. Permeability studies were conducted on rabbits by injection of PSP into (the joint and recovery of the dye from the urine. 2. Cortisone, ACTH, adrenal cortex extract and hydroxyphenylcinchoninic acid (HPC) given to normal rabbits failed to cause any significant alteration of synavial permeability. 3. ACTH given parenterally exhibited a significant antihyaluronidase effect. 4. We agree that the permeability of the joint membrane to PSP is not necessarily a measure of its permeability to normal body substances.
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