The effects of intraperitoneal injections of adrenalin on the partition of nitrogen in the urine of dogs

Abstract

Underhill and Closson have shown that the subcutaneous injection of adrenalin chlorid solutions into dogs is not attended by any significant change in the proportion of the urea, ammonia and creatinin nitrogen of the urine.

In our work we used two specimens of the colorless adrenalin chloride, 1:1000, of Parke, Davis and Co. They were purchased in the open market. Each was tested for its pressor action at the conclusion of the corresponding injection experiments and was then found to be practically as active as ever.

The metabolism experiments were carried out by the methods in use in this laboratory.

Intraperitoneal injection of adrenalin chloride solutions was without effect on the proportions of nitrogen in the forms of urea, ammonia, creatin and creatinin, purins and allantoin.

In one adrenalin injection period of eighteen days, a total of 62 C.C. of a I :10,000 adrenalin solution was given intraperitoneally and in another injection period of six days a total of 29 C.C. of a I :1OOO adrenalin chloride solution was administered.

The following table shows the different percentages of nitrogen for the several experimental periods: