Occurrence of spontaneous lesions in kidneys and livers of rabbits and guinea pigs

Abstract

In view of the importance of the occurrence of spontaneous lesions in the kidneys and in the livers of rabbits and of guinea pigs in reference to the experimental work on these organs, Dr. E. C. Dickson and myself have made a careful study of these organs and incidentally of the heart and of the aorta in fifty rabbits and in one hundred guinea pigs. The animals used were partly fresh animals from the market, partly animals raised at the laboratory.

Many of the rabbits had been used in the physiological laboratory and had been killed immediately after the experiments; some died of coccidiosis; a few had been injected with material supposedly containing pneumococci without result; others had never been used. Several old rabbits that had been in the laboratory for a year or longer were especially selected on account of the greater likelihood of the existence of renal or hepatic lesions in them. Twenty-eight rabbits, among them some of the old ones, had entirely normal kidneys, nine showed slight parenchymatous lesions, three a few small areas of cellular infiltration. In ten we found scattered small areas in which were marked interstitial lesions with the formation of small depressions on the surface. Four of these proved to be radially arranged chronic septic foci which extended from the vicinity of the papilla to the outer surface.