Edema formation in guinea pigs in chronic experimental uranium nephritis

Abstract

In a series of experiments performed on guinea pigs during the past two years, with the purpose of confirming the findings in experimental chronic nephritis which I have previously reported, 1 some interesting observations in edema formation have been made. Twenty-one animals received subcutaneous injections of an aqueous solution of uranium nitrate, as follows: six received numerous injections of 0.5 m.grms. at frequent intervals; eight received several injections of 5 m.grms. at longer and irregular intervals; and seven received one or more injections of 10 to 15 m.grms. Four animals died within two weeks after the first injection, and can be excluded from the chronic nephritis series. The remaining seventeen survived for from three to twenty-three months after the first injection, and all showed kidney lesions of a chronic nature, similar to those which I have previously described.