Abstract
Three out of a series of respiration experiments on sixteen dogs, in which a part or the whole of the hypophysis was removed were reported.
They represented: (1) Extirpation of part of the anterior lobe and all of the posterior lobe. (2) Removal of the anterior lobe, leaving the pars intermedia and the posterior lobe. (3) Complete hypophysectomy.
The amount of gland destruction was determined by serial sections of the brain after the autopsy of the animals. Control experiments were made to determine the effect of the operative procedures without removal of the gland. There was no effect on the carbon dioxide output.
In case if there was a distinct lowering of the carbon dioxide output, and a low level was established which persisted for sixteen days after the operation. At the end of this time the animal, which had previously been retaining nitrogen, was again in nitrogen equilibrium. On autopsy, an increase in fat and atrophy of the ovaries was observed. The weight of the animal had increased.
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