Failure of Rutin and Related Flavonoids to Influence Mortality Following Acute Whole Body X-Irradiation. ∗

Abstract

Summary

1. Rutin, rutin complexed with piperazine hexahydrate, and de-ionized rutin administered to mice by different routes had no protective action against the lethal effects of whole body x-irradiation in doses of 500, 600, 700 or 800 r. 2. Quercitrin, quercetin, hesperidin, hesperidin methyl chalcone, di-hydroquercetin, naringen, calcium flavonate, xanthorhamnin, morin (de-ionized), citrus vit. P (CVP), and lemon juice infusion (LPI), administered in the diet, had no protective action on mice exposed to acute whole body x-radiation. 3. Rutin complex, hesperidin methyl chalcone, and citrus vit. P had no protective effect on rats and guinea pigs exposed to acute whole body x-irradiation. Supplemental vit. C did not enhance the action of the flavonoids or decrease mortality. 4. The LD₅₀ of 250 kvp x-ray, based on the 30-day mortality, for the CF₁ mice used in this experiment, was approximately 550 r.