Abstract
Summary
The effect of cortisone was studied in a dog with malignant multiple mast cell tumors (mastocytoma). A total of 900 mg was given intramuscularly at the rate of 100 mg daily. The tumors rapidly regressed in size so that by the 9th day of treatment they had completely disappeared macroscopically. Microscopically the neoplastic mast cells showed cytoplasmic vacuolization, conglomeration and altered staining reaction of the metachromatic basophilic granules, disappearance of many fine granules, fraying and disruption of the cellular membrane, granule scattering, and, finally, cellular destruction and disappearance. The encouraging results obtained in the treated animal warrant further investigation of cortisone in the treatment of dogs with malignant mast cell tumors.
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