Abstract
Summary
1. Storage of PVP, or of a derivative of PVP, was observed in mice after 12-24 injections of a 3.5% solution. The extent of storage appeared to depend on the mouse strain. 2. Simultaneous administration of PVP and sulfonated azo dyes led to renal excretion of dye; and to a decrease in reticuloendothelial dye storage. 3. PVP administered after dye was given resulted in elution of dye from reticulo-endothelial tissues. 4. PVP administered prior to dye injection prevented storage of dye. 5. On the basis of these findings, an attempt was made to evaluate biologic properties of PVP.
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