Abstract
Summary
Semliki Forest virus multiplied in suspended cell cultures of myxoma tissue to titers of 105.5 to 106.5 LD50 in 48 to 96 hours. In contrast to the usual 100% mortality in myxoma infection, intramuscular inoculations of mouse brain SFV combined with myxoma reduced the myxoma fatality rate to 62%. Myxoma-passed SFV and myxoma injected together intramuscularly killed only 25% of the rabbits. In rabbits that had been infected intracutaneously with myxoma virus 24 hours earlier, intramuscular injection of the 45th passage of SFV in myxoma reduced the myxoma fatality rate from 100% to 51%.
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