Abstract
Summary
Investigations were carried out to determine the effect of Furacin upon the metabolism of mammalian tissue slices using Warburg manometric technics. Inhibition by Furacin was observed in the utilization of glucose by brain, testis, diaphragm, and heart under aerobic conditions. No appreciable inhibition by Furacin was observed in the oxygen uptake of kidney or liver slices either under endogenous conditions or with added glucose. No inhibition of anaerobic glycolysis by Furacin was observed in brain, testis or kidney. Studies on the aerobic utilization of various substrates by brain and kidney slices point to the inhibition by Furacin as occurring in the aerobic utilization of pyruvate.
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