Abstract
Summary
1. A method is described for the preparation of a serologically active antigen from egg yolk material containing spherules. 2. “Spherule antigen” used in a complement fixation test reacted with sera from animals infected with Coccidioides and animals hyperimmunized with the antigen. 3. The antigen was found to stimulate low titers to coccidioidin in hyperimmunized animals. 4. The “Spherule antigen” completely absorbed anti- bodies to the homologous antigen and coccidioidin from the serum of a hypenmmunized rabbit, but failed to absorb antibodies from the serum of a rabbit infected with Coccidioides immitits.
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