Abstract
Summary
1. In a dosage of 2 mg/day cortisone completely halted body growth and produced adrenal atrophy and slight cardiac hypertrophy. Kidney size in intact cortisone-treated rats increased by 25% which, since it occurred in the absence of an increase in body weight, resulted in kidneys which were disproportionately large in relation to body size. 2. Doca in the same dosage was without effect on body weight or heart weight. Slight adrenal atrophy and moderate enlargement of the kidneys in intact animals was observed. 3. Compensatory renal hypertrophy was greatest in controls and diminished to the same extent by either Doca or cortisone. It was suppressed to the greatest extent, but not completely prevented, by a restriction of food intake to a level permitting only maintenance of a static body weight.
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