Abstract
Summary
In embryonic bones growing in tissue culture the process of calcification of cartilage can be inhibited by NaF without influencing growth. To achieve this effect the concentration of fluoride had to be 20 times greater than that which will produce inhibition of calcification in test-tube experiments. The inhibition in the present experiments is probably due to at least two things: lst, interference with the Production of Phospho-Pyruvate as a substrate for bone phosphatase; 2and, some degree of binding of calcium by fluoride.
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