Abstract
Summary
The Lansing complement-fixing (CF) antibody response to immunization in monkeys and to infection in humans appears to be transitory. One hundred thirty-one paralytic poliomyelitis cases in humans were examined for CF antibody to Lansing virus. In the serums of 85 cases, collected 2 weeks after onset of clinical disease, 11 had both neutralizing and CF antibodies. CF antibody was not found in any of 47 cases which were negative for neutralizing antibody. In a series of serum specimens collected from 46 other cases, CF antibody appeared in 10. The CF antibody rose quickly and remained elevated for from 6 weeks to 3 months. A positive CF test may indicate recent infection; a negative, either no exposure or infection at a period remote in the past.
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