Abstract
Summary and Conclusions
1. Crystalline uroporphyrin I has been isolated from the bone marrow of lead poisoned rabbits and found to be identical with uroporphyrin I isolated from the urine of a patient with photosensitive (erythropoietic) porphyria. 2. The bone marrow of rabbits with acute or chronic lead poisoning has been found to contain from 15 to 844 μg of uroporphyrin I per 100 ml. 3. In experimental lead poisoning, significant amounts of uroporphyrin are found in the circulating red blood cells only during the very acute stage. Erythrocyte coproporphyrin is likewise increased markedly only during the acute phase.
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