A New Operative Preparation for Production of Peptic Ulcer in the Dog ∗

Abstract

Summary

1. A method for production of experimental peptic ulcer in dogs is presented. Its advantages are reliability, simplicity of post-operative care, rapidity of ulcer development, and survival of animals in good nutritional condition, thus allowing prolonged study in protected animals. The ulcers are produced without extraneous stimulation. 2. Four groups of animals were studied. The effect of vagotomy alone, antrumectomy alone, and vagotomy combined with antrumectomy are evaluated as to incidence of ulcer and period of survival (an indication of the time required for development of ulcer).