Electrophoretic Studies on Serum and Plasma of Control and Vitamin Deficient Monkeys. ∗

Abstract

Summary

The plasma or serum proteins of rhesus monkeys maintained on various vitamin deficient diets were studied by chemical and by electrophoretic analysis. Partial or complete deficiency of vit. B₆ resulted in hypoalbuminemia and a significant increase in the gamma globulin component. On a niacin deficient diet 2 monkeys developed a lowered albumin and an increase in the gamma globulin. A low choline diet led to a decrease in the albumin and to an increase in the beta globulin. The addition of 1% cholesterol to the diet of control or vit. B₆ deficient monkeys produced a significant increase in the alpha-3 component. The electrophoretic composition of the plasma did not appear to be altered by a state of early chronic scurvy. The mobilities of the plasma components appeared to be increased by an ascorbic acid deficient diet but were unaffected by the other regimens.