Abstract
Summary
1. Lansing virus serum antibody titers in the range of 10-2.0 to 10-3.0 can be achieved in monkeys shortly after the administration of gamma globulin intramuscularly or intravenously. 2. Gamma globulin injected intravenously failed to protect a significant number of monkeys against an intramuscularly challenge of 160 PD50 of Lansing virus. 3. In 2 further experiments, the majority of monkeys receiving high titer immune monkey serum were protected against an intracerebral challenge of 50 and 100 PD50 of Lansing virus respectively. In one experiment only 4/16 test animals became paralyzed as compared to 18/19 controls. In the other experiment 3/18 test animals developed poliomyelitis as compared to all of 20 controls.
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