Abstract
Summary
1. Various amino acids and analogues in concentrations of 1-3 mg/ml inhibit the propagation of Theiler's GDVII strain of mouse encephalomyelitis virus in tissue cultures of one-day-old mouse brain. The most active amino acid was L-lysine which was inhibitory at 0.5 mg/ml. The most effective analogues tested were the ortho-, meta-, or para-fluorophenylalanines, active at 0.1 mg/ml. 2. Partial reversal of lysine inhibition of virus growth was obtained with methionine, leucine, or tyrosine.
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