Ionization and Distribution Between Aqueous and Non-Aqueous Solvents of Dyes in Relation to Gastric Secretion. ∗

Abstract

Summary

In a study of the relation of physical chemical properties of dyes to the extent of their secretion by the. stomach, new determinations of the pK_B values and absorption maxima were made. A somewhat better correlation of pK_B and stomach: blood ratios was obtained by using commercial instead of pure samples of dyes. The distribution of the dyes between benzene and aqueous buffers of pH 2 and pH 6.73 was measured but no satisfactory correlation found. The method is limited by the tendency of compounds to dissolve 100% in either the buffer or the benzene.