Abstract
Summary
In the presence of urea, Micrococcus pyogenes var. aureus produces a urease that is inhibited by furacin, p-chloromercuri-benzoate and trivalent arsenicals. When the organisms are grown in the absence of urea or when furacin-resistant organisms are grown in media containing urea, ureases are obtained that are not affected by the above inhibitors. In explanation of these results as well as those previously reported involving the inhibition of dehydrogenases, it is suggested that some aspects of resistance to the nitrofurans can be explained by a shift of certain enzymes from the SH to a non-SH form.
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