Abstract
Summary
Aureomycin and terramycin in concentrations of 100-300 μg per ml were found to inhibit markedly the respiration of purified murine and epidemic typhus rickettsiae in vitro. Chloramphenicol in concentrations up to 300 μg per ml, aureomycin and terramycin in concentrations up to 30 μg per ml produced only slight inhibition. The inhibition of respiration was correlated with a decrease in the number of viable rickettsiae as determined by toxicity and infectivity for white mice. These experiments demonstrate the rickettsicidal action of aureomycin and terramycin in vitro.
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