Abstract
Conclusions
Parahydroxypropiophenone, when fed to castrate animals at a level of 100 mg a day, behaved like an estrogen by producing cornification of the vagina and hyperplasia and metaplasia of the uterine endometrium. Exogenous thyroid had no added effect other than that produced by parahydroxypropiophenone alone. The evolution of experimental ovarian tumors obtained by transplantation of an ovary to the spleen of a castrated rat was inhibited by parahydroxypropiophenone similarly to that reported when estrogens were given or when splenic adhesions circumventing the portal circulation were present.
Get full access to this article
View all access options for this article.