Abstract
Summary
(1) Terramycin hydrochloride by oral administration in single doses of 50 to 250 mg per kg of weight were not completely curative in the treatment of acute syphilitic orchitis of rabbits. (2) When administered orally twice daily for 15 days in succession the total minimal curative dose was 150 to 300 mg per kg of weight. (3) By intramuscular injection the single minimal curative dose was 75 to 100 mg per kg of weight. When administered once daily for 15 days in succession the total minimal curative dose was 75 to 150 mg per kg by this route of administration. (4) Mapharsen by intravenous injection and bismuth salicylate by intramuscular injection yielded pronounced synergistic or additive therapeutic effects when given along with terramycin hydrochloride by oral and intramuscular administration.
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