Abstract
Summary
A comparison was made of some of the metabolic and morphologic effects of ACTH protein and ACTH peptide given by continuous subcutaneous injection to normal (300 g) male rats for a period of 10 days. The signs of hypercorticalism were adrenal hyperplasia; thymus atrophy, loss in body-weight, rise in urinary NPN, glycosuria and pathologic changes in the stomach and kidneys. ACTH protein had about twice the biologic activity of ACTH peptide as measured by the above criteria, but was significantly less active than the peptide in causing depletion of adrenal ascorbic acid.
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