Abstract
Summary and Conclusions
(1) Permeability studies were performed in rabbits and in patients with rheumatoid arthritis using the method of Seifter which employs injection of PSP into the joint, and recovery of the dye from the urine. (2) Cortisone and ACTH were given to rabbits and patients to determine any effect upon synovial membrane permeability and to detect any anti-hyaluronidase effect in rabbits. (3) Our results fail to demonstrate significant alterations of synovial permeability in rabbits or humans following parenteral therapy with ACTH or Cortisone. There was no evidence of hyaluronidase inhibition in rabbits. (4) Cortisone injected into the joints of rabbits impaired the absorption of PSP. A mechanical blocking effect was not excluded. (5) The injection of PSP into joints is not necessarily a valid measurement of permeability of synovial membranes to physiologic substances.
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