Abstract
Summary
The plasma of laying hens exhibits an inhibitory effect on the interaction of thrombin and fibrinogen. Similar inhibitory activity can be induced in the plasma of chickens of any age and of either sex by the administration of synthetic estrogenic compounds. This effect can be prevented by agents which interfere with normal metabolism of the estrogenic material in the experimental animal. The observed effect is similar to that produced by heparin, but plasma assays have been negative for heparin, and the substance responsible for the heparin-like activity has not been isolated or identified.
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