Abstract
Summary
A strain of rabies isolated from a dog brain and passaged intracerebrally 2 times in Swiss albino mice and one time in cotton rats has been successfully transmitted to the same rodents by the following routes of exposure: intracerebral, intraperitoneal, intradermal, intramuscular, intracardial, intralingual, oral and rectal. The cotton rats and Swiss mice were equally responsive to this strain by the above routes of exposure. Mice were susceptible to intranasal instillation but cotton rats exposed by this method remained symptom free during a 30-day observation period and there was no evidence of Negri bodies when their brains were examined at the end of that time. This strain of virus, which had produced furious rabies in Syrian hamsters in a previous experiment, produced the dumb form of rabies in the cotton rat and Swiss albino mice.
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