Abstract
Summary
Treatment of guinea pigs during the period of sensitization to horse serum with 5 mg/kg of cortisone acetate daily for 20 days did not abolish the Arthus reaction or affect the level of tissue antibody as measured by the anaphylactic response of the isolated ileum. Injection of 25 mg intraperi-toneally 4 1/2 and 6 1/2 hours before sacrifice likewise had no effect. Cortisone acetate in vitro had no effect on the antigen-antibody reaction of the Arthus type. Ethyl alcohol, at a concentration of 0.8%, usually abolished the anaphylactic response. Some blockade of the antigen-antibody reaction by sodium salicylate was indicated. The histamine sensitivity of the isolated ileum was not affected by cortisone acetate treatment in vivo or in vitro.
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