Abstract
Summary
The present study concerns itself with a titration of the encephalitogenic activity of mouse brain which induced acute disseminated encephalomyelitis in mice. In this regard the active agent revealed a potency higher than that hitherto described for the guinea pig receiving homologous tissue. The encephalitogenic factor was found not in the supernate but in the sediment after centrifugation at 8000 G; nor was it detected in a dialysate of mouse-brain tissue. Mouse brain was encephalitogenic in a heterologous species of animal and heterologous tissues were similarly encephalitogenic in the mouse; the disorder thus brought about by either was indistinguishable from that induced in mice by means of mouse brain.
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