Abstract
Summary
(1) A new chemical compound has been found which has high oral and parenteral parasympathetic blocking activity. This compound, N,N dimethyl 4-piperidyli-dene 1,1 diphenylmethane methyl sulfate (Prantal), is unique in its specificity of action within the parasympathetic system, i.e., it primarily inhibits gastric motility and gastric secretion. The intravenous sympathetic ganglion blocking dose is 50 to 100 times that required for intravenous parasympathetic blockade. (2) In dogs, roentgenologic observations of the movement of barium sulfate from the stomach indicate that orally administered Prantal delays gastric emptying time more effectively, and is longer acting than methantheline bromide. Additional dog experiments showed the ability of Prantal to reduce the volume and titratable total acid of gastric secretions. (3) After oral medication in dogs, Prantal produced no mydriasis at doses which inhibit gastric motility for several hours, whereas methantheline bromide caused mydriasis which persisted for one to 3 hours. In rabbit (tests by topical application to the eye, mydriasis occurred with a 0.1% concentration of methantheline bromide, whereas 1.0% of Prantal was not mydriatic; mydriasis occurred at the 2.0% concentration of Prantal. By intravenous injection in rabbits methantheline bromide caused mydriasis at 1.0 and 2.0 mg/kg doses; no mydriasis occurred at 2.0, 4.0 or 8.0 mg/kg doses of Prantal.
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