Abstract
Summary
(1) A pulsatile perfusion system is described in which temperature, blood flow and mean pressure are controlled, and in which red blood cell solutions may be satisfactorily perfused through isolated limbs and organs. (2) In hind limbs perfused with blood of low colloidal content, 5.5 to 9.4 vol. % oxygen content were adequate in maintaining capillary function since a minimal rate of edema formation was observed which did not vary appreciably with flow. (3) Hind limbs perfused with 0.88 to 2.60 vol. % oxygen exhibited augmented edema formation which increased with increased flow. The critical hypoxemia level affecting capillary permeability is believed to lie between 2.6 and 5.5 vol. °/o oxygen content for the experimental conditions described.
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