Abstract
Summary
Exposure of citrovorum factor (leucovorin) solutions to pH 2 for 24 hours at 25 °C resulted in inactivation of L. citrovorum activity but produced no alteration in the activity for S. faecalis. The acid-treated leucovorin was about one-tenth as active as leucovorin in reversing Aminopterin toxicity in mice. When administered to patients with pernicious anemia in relapse the acid-treated leucovorin was less active than leucovorin.
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