Abstract
Summary
A method is described for recording in vitro pressure responses from perfused segments of small blood vessels. The method permits accurate evaluation of the relationships between dose and response. For arterial biopsy specimens from the dog's mesentery, maximal pressure responses of 200 to 300 mm Hg are obtained with test doses of epinephrine at an intravascular concentration of about 1.0 γ/ml. The threshold for response is about 0.04 γ/ml. The latent period for chemical stimulation of these specimens is approximately 3 to 4 seconds.
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