Excretion and Distribution of Radioactive S 35 -Cyclamate Sodium (Sucaryl Sodium) in Animals. ∗ ‡

Abstract

Summary

1. The excretion and distribution of S³⁵-sucaryl in the tissues of the rat, dog, and rabbit were studied. 2. By means of cold isotope dilution and paperchromato-graphic methods, it was shown that in the rat at least 95% of the material was excreted unchanged. 3. Single doses up to 3.2 g/kg intra-peritoneally were rapidly excreted by the rat in 24 hours. A dose of 1.4 g/kg was excreted with equal rapidity by normal and a unilaterally nephrectomized rat. 4. With repeated oral dosing in rats about two-thirds of the drug was excreted in the feces and one-third in the urine. No significant amounts of S³⁵ sucaryl were found to be stored in the body. 5. In the dog only 0.5% of the injected S^35-sucaryl was found in the bile 5 hours after an intravenous injection of 9.7 mg/kg. 6. With the exception of the kidney and perhaps the liver, there was no significant concentration of the drug in the various organs of the rat, rabbit, and the dog. Sucaryl penetrated into the brain with difficulty, but was found in the fetus of the rat.