Abstract
Summary
Adrenalectomy resulted in an increase in total count and increased absolute numbers of mononuclear and eosinophilic cells in the circulating blood of adrenalectomized mice. The increases were progressively greater with increases in the length of the interval after adrenalectomy from 4-5 days to 17-30 days. There was no consistent effect on neu-trophiles. Reticulocyte percentages increased in the circulating blood. The number of mitotic figures in the bone marrow was reduced, while the ratio of myeloid to erythroid elements was increased. All the differences noted were found to be significant. The results suggest a decreased rate of activity and of maturation of cells in the bone marrow and an increase in the length of period of maturation and longevity in the circulating blood.
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