Abstract
Summary
A study of factors influencing citrate synthesis was conducted using the fluoroacetate technique of Potter(2) to determine the cause of the marked sex difference (1) in citrate accumulation in the liver following administration of fluoroacetate to rats. Castration of female rats did not decrease citrate synthesis in the liver but castrated and adrenalectomized male rats acquired the ability to accumulate citric acid in the liver after fluoroacetate treatment. Administration of testosterone to female rats for several days decreased citrate synthesis in the liver and testosterone inhibited citrate synthesis by rat liver homogenates in vitro. The results of these experiments indicated that androgens suppress citrate formation in the liver.
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