Abstract
Summary
(1) A spectrophotometric method has been developed for the determination of nicotinaldehyde thiosemicarbazone in blood. (2) Following single oral doses of 200 mg/kg in dogs, the maximum blood concentration achieved by nicotinaldehyde thiosemicarbazone was ten to forty times greater than that of p-acetylaminobenzaldehyde thiosemicarbazone. (3) Following the chronic daily oral ingestion of 0.05% of these drugs in the diet of rats? the average blood concentration attained by nicotinaldehyde thiosemicarbazone was approximately 10 times that attained by p-acetylaminobenzaldehyde thiosemicarbazone.
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