Abstract
Summary
Prior administration of beef adrenal extract increased the resistance of mice, particularly male mice, to semi-lethal doses of arsenite, oxophenarsine and clorarsen. Male mice were protected against arsenite by cortisone and ACTH, but not by desoxycorti-costerone. Prior administration of cortisone did not increase the resistance of mice to semi-lethal doses of p-chloromercuribenzoate, iodo-acetamide, alphapeltatin, or 9-phenyl-9-chlor-10-methyl-3-dimethyl amino acridan. The minimum dose of arsenite required to induce marked hemorrhagic necrosis in mouse Sarcoma 37 was somewhat greater for adrenal extract or cortisone injected mice than for control mice.
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