Abstract
Summary
1. After intravenous injection into dogs, the following compounds were found to be good cholecystographic dyes: N-(3-amino-2,4,6-triiodobenzoyl) e-amino-n-caproic acid (Compound 6); 2-(4-hydroxy-3,5-diiodo-benzyl) benzoic acid (Compound S); 3-cap-roylamino-2,4,6-triiodobenzoic acid (Compound 5) and 3-butyrylamino-2,4;6-triiodo-benzoic acid (Compound 4). After oral administration, only Compounds S and 6 produced satisfactory visualization of the gall bladder and biliary tract 16 hr after feeding. 2. Analyses of the tissues of rats after intravenous administration of the compounds (1-6 inclusive and S) gave the following results: In the liver, Compound 6 was present in greater concentration than any of the others tested; in the kidney, Compounds 3-formyl-amino-2,4,6-triiodobenzoic acid, 3-acetylami-no-2,4,6-triiodobenzoic acid, 3-propionylami-no-2,4,6-triiodobenzoic acid, and 3-butyryl-amino-2,4,6-triiodobenzoic acid were present in high concentration during the initial intervals, but fell to a relatively low level at the end of 3 hr. It was found that the rates of excretion of these compounds by the kidney decreased with the increase in the length of the acyl group.
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