Quantitative Biologic Activity of Δ 4,6 dehydrocortisone as Compared to Cortisone. ∗

Abstract

Summary

Cortisone acetate and Δ^4,6dehydrocortisone acetate were compared in the muscle-work test and by the liver glycogen deposition test. According to these criteria the quantitative potency of the diene is probably no greater than 50% of the potency of cortisone acetate. It is suggested that the reported differences in the biologic properties of these two compounds may be explicable by the assumption that larger doses of the diene would cause biologic responses which are identical with those caused by cortisone.